Kısıtlama ve Soğuk Kısıtlama Stresinin Wistar Albino Sıçanlarda Pıhtılaşma Göstergeleri Üzerindeki Etkileri

The purpose of this study was to investigate the effects two different acute stress protocols, such as restraint and cold stress, on coagulation indicators in rats. conducted 18 male Wistar albino rats aged 8-10 weeks with a body weight 180-220 g. After one-week adaptation period, were randomly divided into three groups (n=6/group). animals control group not exposed any stress. Rats housed restrainer designed for rats, their movement restricted 2 hours at room temperature. kept +4°C hours. Blood samples collected by cardiac puncture under ketamine xylazine anesthesia Vacutainer® tubes containing 3.2% sodium citrate (0.109 M trisodium citrate). Coagulation (aPTT, PT, INR, fibrinogen, D-dimer) analyzed using an automated analyzer (Roche Cobas t511, Switzerland). Although (restraint stress) had no effect aPTT D-dimer levels (p>0.05), it increased PT INR values (p